Publications by authors named "T V Kuznetzova"
Purpose: To assess the suppression of tumorogenicity 2 (ST2) and copeptin significance for risk stratification of patient (pts) with acute decompensated heart failure (ADHF) during long-term follow-up compared with traditional risk factors.
Methods: We included in a prospective study 159 pts with ADHF. Blood samples to determine copeptin, sST2, NT-proBNP and hsTnT concentration were collected at admission and at discharge from the hospital.
In the present review, we focus on the phenomenon of chromothripsis, a new type of complex chromosomal rearrangements. We discuss the challenges of chromothripsis detection and its distinction from other chromoanagenesis events. Along with already known causes and mechanisms, we introduce aberrant epigenetic regulation as a possible pathway to chromothripsis.
View Article and Find Full Text PDFThis manuscript reports on genomewide epigenetic alterations in cri-du-chat syndrome related to a partial aneusomy of chromosome 5. A systematic analysis of these alterations will open up new possibilities for the prognostic evaluation of CDCS patients and the development of new therapeutic interventions for reducing the severity of the disease.
View Article and Find Full Text PDF[Role of and genes polymorphisms in the pathogenesis of stroke of the Erzya population in the Republic of Mordovia].
Zh Nevrol Psikhiatr Im S S Korsakova
May 2019
Aim: To determine the frequency of GPIIIa and eNOS genes polymorphisms in patients with ischemic stroke in the Erzya population in the Republic of Mordovia.
Material And Methods: An open, prospective, randomized study included 4 groups: 1) Erzya with ischemic stroke (main group, n=65), 2) Russians with ischemic stroke (comparison group, n=60), 3) Erzya healthy volunteers (control-1, n=63), 4) Russian healthy volunteers (control-2, n=61). T1565C polymorphism of GPIIIa gene (rs5918) and G894T polymorphism of eNOS gene (rs1799983) were determined by real-time PCR.
Article Synopsis
- The study analyzed DNA hydroxymethylation and methylation in human testicular cells and sperm from azoospermic patients and sperm donors, finding that while methylation was consistent throughout spermatogenesis, hydroxymethylation varied and was mostly low in sperm samples.
- High levels of hydroxymethylcytosine were primarily found in a small population of sperm cells, indicating that variations in hydroxymethylation patterns are likely not genetically programmed but may indicate abnormalities.
- Increased levels of hydroxymethylated sperm correlated negatively with markers of good semen quality and positively with sperm DNA fragmentation, suggesting that hydroxymethylation could serve as a new indicator for assessing sperm quality in infertile couples.