[Relationship between polymorphism of non-coding regions of human mitochondrial genome and primary cardiac conduction disorders].

Aim: Analysis of associations between idiopathic disturbances of cardiac conduction (DCC) and polymorphism of mitochondrial genome.

Material And Methods: A family examination was performed in 431 probands with various DCC and 1347 relatives of the first, second and third degree of kinship (the study group). All the examinees were divided into four subgroups.

[Angiotensin-converting enzyme gene polymorphism in patients with primary disturbances of cardiac conduction].

Increased frequencies of angiotensin-converting enzyme (ACE) D-allele and ID-genotype among patients with idiopathic atrioventricular blocks and I allele and II genotype among patients with idiopathic intraventricular blocks allow to consider these genotypes risk factors of corresponding disturbances of cardiac conduction. Decreased frequency of ACE I allele and II genotype among patients with idiopathic atrioventricular blocks is indicative of a possible protective role of II genotype against development of this type of cardiac conduction defect. Low frequency of D allele and genotype D prevents derangements of conduction in His-Purkinje system.

[Connection of the polymorphic variant T174M angiotensinogen gene with coronary atherosclerosis in the Tomsk population].

Allele and genotype frequencies of the T174M polymorphism of the angiotensinogen gene were for the first time estimated in the West Siberian population. The polymorphism was tested for association with coronary atherosclerosis (CAS) and with several quantitative risk factors in patients with angiographically verified CAS, healthy individuals, and in a population sample nondifferentiated with respect to CAS.

[Polymorphism T174M of the angiotensinogen gene in Siberian populations].

The level of T174M polymorphism of the angiotensinogen gene (AGT) was studied for the first time in Siberian populations. The frequency of allele M was found to be 7% in Russians, 6% in Tuvinians, and 4% in Buryats. In the Mongoloid population of Siberia (Tuvinians and Buryats), the genotypic frequencies deviated from Hardy-Weinberg equilibrium (P < 0.