[Doses levorin display an antiandrogenic action?].

The antiandrogenic effect of levorin on immature castrated rats treated with exogenic testosterone was studied. In a dose of 200 mg/kg levorin lowered the cholesterin blood levels in the rats, inhibited the testosterone-induced increase in RNA concentration in the ventral and dorsal prostate and the seminal vesicles and to a less extent suppressed the growth of the accessory sexual glands. However, the antiandrogenic effect was observed with the use of levorin in the dose producing a pronounced toxic action evident from death of a part of the animals and a marked decrease in the animal body weight.

[Effect of proteolytic enzymes on antibiotic distribution when the preparations are administered by different routes].

The effect of proteolytic enzymes, such as terrilitine and chymotripsin on pharmacokinetics of morphocycline and streptomycin in rats after their administration by various routes was studied comparatively. The oral use of the enzymes or their introduction directly into the duodenum simultaneously or 30 minutes before the antibiotic administration did not increase the morphocycline and streptomycin levels in the biosubstrates tested. A tendency to a decrease in the serum and organ levels of the antibiotics in animals when used orally in combination with the enzymes was noted.

[Chlorlincocin kinetics in animals with a disordered hormonal balance].

Distribution of chlorlincomycin in intact rats and animals with an impaired hormonal balance was studied. Estradiol or hydrocortizon acetate were administered repeatedly to the animals in large doses with a purpose of inducing pathological conditions. Chlorlincomycin was administered intravenously for 11 days in a dose of 15 mg/kg.

[Effect of amphotericin B and its combination with 5-fluorouracil on the development of transplantable rat lymphosarcoma].

The studies were carried out on rats with subcutaneously transplanted metastizing Pliss lymphosarcoma. The animals were treated with amphotericin B administered intravenously in complex with sodium desoxycholate in doses of 336 and 20 Units/kg for 7 days beginning from 24th hour after the tumor transplantation. The treatment resulted in a statistically reliable inhibition of the tumor metastasizing as compared to the control animals.