[Epidemiology and diagnosis of mutations in the ALK gene in patients with non-small cell lung cancer in the Moscow region].

Aim Of Study: To determine a diagnostic algorithm for detecting translocation of the gene and its frequency in the Moscow region.

Materials And Methods: During the priod between 2014 and 2018 (inclusive), 488 patients without activating mutations in the gene in the Moscow region were tested. To detect translocation of the ALK gene, fluorescence hybridization (FISH) methods, an immunohistochemical method, and, in some cases, a polymerase chain reaction were used.

Distribution of EGFR Mutations in 10,607 Russian Patients with Lung Cancer.

Introduction: This study was aimed to evaluate distribution of epidermal growth factor receptor (EGFR) mutations in a large series of Russian lung cancer (LC) patients.

Methods: 10,607 LC samples were considered for EGFR analysis; EGFR status was successfully determined in 10,426 cases (98.3 %), indicating relatively low failure rate.