[INTRAHEPATIC CHOLESTASIS OF PREGNANCY: STATE-OF-THE-ART].

Intrahepatic cholestasis of pregnancy (ICP) is a relatively benign cholestatic pathology of the liver developing in II or III trimester of pregnancy and characterized by itchy skin and enhanced serum bile acid levels. The cause of ICP is unknown; it may have a multifactor nature involving genetic (ABCB4, EXR, ABCC2 genes), hormonal (estrogens, progesterone), and environmental factors. As a rule, ICP first manifests itself on weeks 28-30 of pregnancy in the form of pruritus especially pronounced at night time.

[Reproductive potential of women with epilepsy].

An aim of the article was to study reproductive health of 218 women with epilepsy who were long-term treated with antiepileptic drugs (AED). A comparison group included 47 patients with polycystic ovary syndrome (PCOS). Women with epilepsy were stratified into 2 groups: group 1 included 107 women of reproductive age and group 2 - 111 pregnant women with epilepsy.