Gene-gene interactions between glutathione-s transferase M1 and matrix metalloproteinase 9 in the formation of hereditary predisposition to chronic obstructive pulmonary disease.

The incidence of allele variants of glutathione-S transferase M1 xenobiotic detoxification gene and matrix metalloproteinase 9 gene was analyzed in patients with chronic obstructive pulmonary disease. A strict gene-gene interaction between these two genes in the formation of hereditary predisposition to this disease was first demonstrated. The combination of glutathione-S transferase M1 genotype 0/0 and matrix metalloproteinase 9 mutant allele (-15621) is a risk factor for chronic obstructive pulmonary disease (OR-7.

[Prognostication of obstructive syndrome in patients with chronic bronchitis considering hereditary factors].

Aim: To propose method of accurate prediction of chronic obstructive pulmonary disease (COPD) at early stages of development.

Material And Methods: 92 males with COPD and 55 males with chronic non-obstructive bronchitis aged 38 to 72 years were examined according to a technique which identifies hereditary predisposition to multifactor diseases and using an algorithm based on multivariate analysis.

Results: An original mathematical model is proposed which can quantitatively examine and range by influence the role of environmental and hereditary factors in development of COPD.