Behaviour of the model antibody fluid constrained by rigid spherical obstacles: Effects of the obstacle-antibody attraction.

This study investigates the behaviour of a fluid of monoclonal antibodies (mAbs) when trapped in a confinement represented by rigid spherical obstacles that attract antibodies. The antibody molecule is depicted as an assembly of seven hard spheres (7-bead model), organized to resemble a -shaped object. The model antibody has two Fab and one Fc domains located in the corners of letter .

Empty liquid state and re-entrant phase behavior of the patchy colloids confined in porous media.

Patchy colloids with three and four equivalent patches, confined in an attractive random porous medium, undergo re-entrant gas-liquid phase separation with the liquid phase density approaching zero at low temperatures. The (bonding) colloid-colloid interaction causes the liquid-gas phase separation, which is modulated by the presence of the randomly distributed hard-sphere obstacles, attracting the colloids via Yukawa potential. Due to this interaction, a layer of mutually bonded colloids around the obstacles is formed.

Aggregation, liquid-liquid phase separation, and percolation behaviour of a model antibody fluid constrained by hard-sphere obstacles.

This study is concerned with the behaviour of proteins within confinement created by hard-sphere obstacles. An individual antibody molecule is depicted as an assembly of seven hard spheres, organized to resemble a Y-shaped (on average) antibody (7-bead model) protein. For comparison with other studies we, in one case, model the protein as a hard sphere decorated by three short-range attractive sites.

Phase Equilibria of Polydisperse Square-Well Chain Fluid Confined in Random Porous Media: TPT of Wertheim and Scaled Particle Theory.

Extension of Wertheim's thermodynamic perturbation theory and its combination with scaled particle theory is proposed and applied to study the liquid-gas phase behavior of polydisperse hard-sphere square-well chain fluid confined in the random porous media. Thermodynamic properties of the reference system, represented by the hard-sphere square-well fluid in the matrix, are calculated using corresponding extension of the second-order Barker-Henderson perturbation theory. We study effects of polydispersity and confinement on the phase behavior of the system.

Two- and three-phase equilibria of polydisperse Yukawa hard-sphere fluids confined in random porous media: high temperature approximation and scaled particle theory.

We have studied the phase behavior of polydisperse Yukawa hard-sphere fluid confined in random porous media using extension and combination of high temperature approximation and scaled particle theory. The porous media are represented by the matrix of randomly placed hard-sphere obstacles. Due to the confinement, polydispersity effects are substantially enhanced.