Publications by authors named "T V Colby"
Article Synopsis
- The KEAP1-NFE2L2 pathway is crucial for how cells respond to metabolic and oxidative stress, regulating the levels of NFE2L2, a key transcription factor that activates protective genes.
- Infection by Legionella pneumophila triggers a process where the autophagy receptor SQSTM1 is modified, preventing its binding to KEAP1, leading to the degradation of NFE2L2 and a drop in antioxidant gene expression during the early phase of infection.
- As the infection progresses, serine ubiquitination levels of SQSTM1 decrease, allowing the activation of NFE2L2-target genes, which differentially affects the host's metabolome and proteome.
Context.—: Mesothelioma is an uncommon tumor that can be difficult to diagnose.
Objective.
Background: The prognostic and theragnostic role of histopathological subsets in systemic sclerosis interstitial lung disease (SSc-ILD) have been largely neglected due to the paucity of treatment options and the risks associated with surgical lung biopsy. The novel drugs for the treatment of ILDs and the availability of transbronchial cryobiopsy provide a new clinical scenario making lung biopsy more feasible and a pivotal guide for treatment. The aim of our study was to investigate the usefulness of lung biopsy in SSc ILD with a systematic literature review (SLR).
View Article and Find Full Text PDFMembers of the Fleischner Society have compiled a glossary of terms for thoracic imaging that replaces previous glossaries published in 1984, 1996, and 2008, respectively. The impetus to update the previous version arose from multiple considerations. These include an awareness that new terms and concepts have emerged, others have become obsolete, and the usage of some terms has either changed or become inconsistent to a degree that warranted a new definition.
View Article and Find Full Text PDFContext.—: The pathologic diagnosis of usual interstitial pneumonia (UIP) remains a challenging area, and application of histologic UIP guidelines has proved difficult.
Objective.