Publications by authors named "T V Byzova"
Aims: In the context of atherosclerosis, macrophages exposed to oxidized low-density lipoprotein (oxLDL) exhibit cellular abnormalities, specifically in adhesome functions, yet the mechanisms and implications of these adhesive dysfunctions remain largely unexplored.
Methods And Results: This study reveals a significant depletion of Kindlin3 (K3) or Fermt3, an essential component of the adhesome regulating integrin functions, in macrophages located within atherosclerotic plaques in vivo and following oxLDL exposure in vitro. To examine the effects of K3 deficiency, the study utilized hyperlipidemic bone marrow chimeras devoid of myeloid Kindlin3 expression.
The etiology of hair loss remains enigmatic, and current remedies remain inadequate. Transcriptome analysis of aging hair follicles uncovered changes in immune pathways, including Toll-like receptors (TLRs). Our findings demonstrate that the maintenance of hair follicle homeostasis and the regeneration capacity after damage depend on TLR2 in hair follicle stem cells (HFSCs).
View Article and Find Full Text PDFBackground: Biological sex differences play a vital role in cardiovascular diseases, including atherosclerosis. The endothelium is a critical contributor to cardiovascular pathologies since endothelial cells (ECs) regulate vascular tone, redox balance, and inflammatory reactions. Although EC activation and dysfunction play an essential role in the early and late stages of atherosclerosis development, little is known about sex-dependent differences in EC.
View Article and Find Full Text PDFArticle Synopsis
- - Akt3, a member of the AKT protein kinase family, plays a role in various cellular processes, and its enhanced activity was studied to understand its impact on atherosclerosis in a mouse model.
- - Crossbreeding atherosclerosis-prone ApoE mice with those having boosted Akt3 activity showed a significant decrease in atherosclerotic lesions and macrophage presence when fed a Western-type diet.
- - The study highlighted that increased Akt3 activity in bone marrow-derived cells offers protection against atherosclerosis, particularly in male mice, by reducing inflammatory cytokine levels and enhancing macrophage resistance to cell death.
The etiology of hair loss remains enigmatic, and current remedies remain inadequate. Transcriptome analysis of aging hair follicles uncovered changes in immune pathways, including Toll-like receptors (TLRs). Our findings demonstrate that the maintenance of hair follicle homeostasis and the regeneration capacity after damage depends on TLR2 in hair follicle stem cells (HFSCs).
View Article and Find Full Text PDF