[Somatic pathology in elderly and senile persons suffering from Alzheimer's disease and Alzheimer's type dementia.].

In order to study the prevalence of chronic somatic age-associated pathology in elderly and senile people suffering from Alzheimer's type dementia with the presentation of the hypothesis of somatopsychic pathogenetic comorbidity observation and treatment, 217 patients were observed, conditionally divided into 2 comparable groups: with a definitive diagnosis of Alzheimer's disease (n=73) and with so-called Alzheimer's type dementia (n=144). Distinct differences in the variants of comorbid to the selected types of dementia of somatic pathology were determined, which had a negative impact not only in terms of the occurrence of cognitive disorders, but also in the future, during the formation of the most severe variants of dementia. In cases of Alzheimer's disease, pathological processes in the large intestine turned out to be leading, with Alzheimer's type dementia - diseases of the circulatory system and type 2 diabetes mellitus.

[The possibility of using the results of the study of oral fluid and buccal epithelium in the diagnosis of Alzheimer's disease.].

The article presents the results of the first experience of comparative studies of the state of the oral fluid and buccal epithelium in 12 patients suffering from Alzheimer's disease, and in 12 individuals without any signs of cognitive impairment. In the course of the study, the correlative relationships of pro-inflammatory and anti-inflammatory factors of the oral fluid, the main cytological changes of the buccal epithelium with the results obtained during neuropsychological testing using the MMSE and ADAS-COG scales were studied. This comparative study is associated with the assumption of a common ectodermal origin of the nervous tissue and buccal epithelium, which may be due to systemic pathological changes in the tissues of a single embryonic embryo leaf.

[The dependence of medical and diagnostic measures carried out in geriatrics on age, gender and the doctor's health status.].

The article discusses the probable dependence of the actions of a specialist working with geriatric patients on the age, gender, and other characteristics of this specialist. This seemingly unconventional approach to research in the field of gerontology and geriatrics reveals distinct differences in a number of aspects of clinical thinking and following clinical recommendations in doctors of different ages, genders, and in different states of their own health. On the basis of a survey of 126 doctors and an analysis of 2 394 of their opinions, the results were obtained, indicating a certain conservatism of doctors over the age of 50, especially men with extensive clinical experience.

[Indicators of the hormonal spectrum in the acute period of stroke in representatives of different gender and age with different degrees of severity of functional disorders.].

The level of serum levels of a number of hormones in the acute period of stroke was determined in 29 men and 29 women aged 45 to 88 years. Comparison of the results obtained was carried out in relation to the age of the patients and the severity of the functional defect formed at the end of the acute period of stroke. The most pronounced dynamics in relation to different severity of functional disorders was found for cortisol, aldosterone and estradiol (p=0,014-0,022) in men under the age of 60 years and for testosterone (p=0,001-0,0001) in men 60-88 years.

[Cognitive aging and cognitive reserve: point of contact.].

The high risk of cognitive disorders in the elderly and senile age makes, on the one hand, to look for their causes, on the other - the possibility of prevention. In this regard, in recent years, the concept of cognitive reserve has become widespread, implying a set of quantitative parameters of the brain and its ability to maintain high functional activity in the process of aging and against the background of age-related brain pathology. The material presented in the article on the basis of the review of scientific literature highlights two main points concerning the possibility of preserving the cognitive reserve-gender and educational factors.