Genomic epidemiology of SARS-CoV-2 in Russia reveals recurring cross-border transmission throughout 2020.

In 2020, SARS-CoV-2 has spread rapidly across the globe, with most nations failing to prevent or substantially delay its introduction. While many countries have imposed some limitations on trans-border passenger traffic, the effect of these measures on the global spread of COVID-19 strains remains unclear. Here, we report an analysis of 3206 whole-genome sequences of SARS-CoV-2 samples from 78 regions of Russia covering the period before the spread of variants of concern (between March and November 2020).

Multi-Server Approach for High-Throughput Molecular Descriptors Calculation based on Multi-Linear Algebraic Maps.

The present report introduces a novel module of the QuBiLS-MIDAS software for the distributed computation of the 3D Multi-Linear algebraic molecular indices. The main motivation for developing this module is to deal with the computational complexity experienced during the calculation of the descriptors over large datasets. To accomplish this task, a multi-server computing platform named T-arenal was developed, which is suited for institutions with many workstations interconnected through a local network and without resources particularly destined for computation tasks.

[Effects of cerebrolysin on the oxidant homeostasis, the content of microelements and electrolytes in children with minimal brain dysfunction].

In 36 children of 3-8 years old with minimal cerebral dysfunction there were evaluated both concentrations of malonic dialdehyde in blood plasma, erythrocytes and platelets as well as the content of 25 elements (K, Mg, Ca, Na, P, Se, Zn, Co, Cr, Cu, Fe, Mn, Mo, Si, Li, Ni, V, Pb, Sn, Cd, Al, As, Be, Bi, Ti) in hairs. These indices were estimated both before and after course of cerebrolysin therapy (the a dose 2-5 ml intramuscularly during 1 month). There was observed positive influence of the drug on the clinical manifestations of the disease, oxidant and elements homeostasis.