Barrett's esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC), but its cellular origin and mechanism of neoplastic progression remain unresolved. Notch signaling, which plays a key role in regulating intestinal stem cell maintenance, has been implicated in a number of cancers. The kinase Dclk1 labels epithelial post-mitotic tuft cells at the squamo-columnar junction (SCJ), and has also been proposed to contribute to epithelial tumor growth.
View Article and Find Full Text PDFZh Nevrol Psikhiatr Im S S Korsakova
August 2019
Aim: To study the efficacy of medical rehabilitation outpatient program 'Point of Soberness' with the use of prolonged injectable naltrexone for alcohol dependent parents of minor children.
Material And Methods: One hundred and seventeen patients with severe disease form without remissions were enrolled in the study. All patients were parents at risk of deprivation of parental rights.
Hum Psychopharmacol
November 2018
Introduction: Although pharmacogenetic tests provide the information on a genotype and the predicted phenotype, these tests themselves do not provide the interpretation of data for a physician. There are currently approximately two dozen pharmacogenomic clinical decision support systems used in psychiatry. Implementation of clinical decision support systems capable of forming recommendations on drug and dose selection according to the results of pharmacogenetic testing is an urgent task.
View Article and Find Full Text PDFZh Nevrol Psikhiatr Im S S Korsakova
May 2019
Aim: To study the efficacy of nooclerin (deanoli aceglumas) in alcohol withdrawal syndrome assessed by clinical and biochemical characteristics.
Material And Methods: A multicenter, open, randomized, comparative study of nooclerin in the complex treatment of alcohol withdrawal syndrome included 90 patients. The patients were randomized into nooclerin group (n=55) and control group (n=35).