[Detection of novel genetic markers of susceptibility to preeclampsia based on an analysis of the regulatory genes in the placental tissue].

Regulatory single nucleotide polymorphisms (rSNPs) are the least-studied group of SNP; however, they play an essential role in the development of human pathology by altering the level of candidate genes expression. In this work, we analyzed 29 rSNPs in 17 new candidate genes associated with preeclampsia (PE) according to the analysis of the transcriptome in placental tissue. Three ethnic groups have been studied (yakut, russian, and buryat).

[A method for determining the heart moving electric center on surface distributed models of the cardioelectric generator].

Using mathematical models of the bioelectric generators of the heart with surface distributed configurations, it was shown that the coordinates of the moving electric center of the heart can facilitate the recognition of the global spatial position of electrogenic zones in the myocardium. These coordinates were determined by the previously proposed method from the cardioelectric potential measured noninvasively with a multichannel lead system in the framework of electrocardiographic mapping.

[Mobile cardiac electrical center: a new concept and mathematical modeling].

A method for determination of the cardiac electric center on the basis of noninvasive multichannel measurements and multipole description of the cardioelectric potential is proposed. The method provides a more accurate and stable spatial location of the cardioelectric generator as compared to other methods (in particular, those based on minimization of the quadrupole potential). The position of the electric center is a useful characteristic for topical diagnosis of the electrophysiological state and function of the heart.