Publications by authors named "T Umazume"
Cell-free DNA (cfDNA) is present in healthy individuals but is elevated in those undergoing physical exertion, trauma, sepsis, and certain cancers. Maintaining cfDNA concentrations is vital for immune homeostasis and preventing inflammatory responses. Understanding cfDNA release and clearance is essential for using cfDNA as a biomarker in clinical diagnostics.
View Article and Find Full Text PDFFolates are essential nutrients for fetal development during pregnancy. Valproic acid (VPA), an inhibitor of histone deacetylases (HDACs), alters the expression of folate carriers in placental cells; however, the underlying mechanisms remain unclear. Here, we aimed to determine the profiles of folate carriers (folate receptor alpha [FOLR1], solute carrier [SLC]-19A1, and SLC46A1) after inhibition of HDACs, especially class I and IIa HDACs, using different inhibitors and gene knockdown tests.
View Article and Find Full Text PDFArticle Synopsis
- - Pharmaceutical care is crucial for mental health during the perinatal period, especially for managing insomnia, leading to an increased use of melatonin receptor agonists (MRAs) and dual orexin receptor antagonists (DORAs).
- - A new analytical method (UPLC-MS/MS) was developed to measure levels of specific MRAs and DORAs in human plasma and breast milk, assessing their safety and transfer to breastfeeding.
- - The method utilized various extraction techniques and was validated for clinical use, revealing that the milk-to-plasma (M/P) ratio for lemborexant was less than 1, indicating limited transfer to breast milk.
Background: Breastfeeding is considered to be the most effective way of ensuring the health and survival of newborns. However, mammary transfer of drugs administered to mothers to breastfeeding infants remains a pressing concern. Acetaminophen and diclofenac sodium are widely prescribed analgesics for postpartum pain relief, but there have been few recent reports on the mammary transfer of these drugs, despite advances in analytic techniques.
View Article and Find Full Text PDFAim: This study aimed to determine the weight gain during pregnancy that minimizes the predicted probability of various perinatal adverse events according to the pre-pregnancy body mass index (BMI) and make recommendations for optimal weight gain in Japan.
Methods: The Japan Society of Obstetrics and Gynecology perinatal database for 2015-2017 was used. From the 719 723 deliveries included in this database, parturients with underlying diseases or missing data were excluded, and 419 114 deliveries were analyzed.