Publications by authors named "T UBUKA"
Article Synopsis
- Lecanemab, an FDA-approved antibody drug for Alzheimer’s, raises concerns about its minimal biological effects, potential side effects, and high costs.
- Non-drug treatments may improve cognitive resilience with fewer side effects and lower economic impact.
- It's essential to evaluate the pros and cons of both drug and non-drug approaches, especially for older patients with Alzheimer’s, to prioritize safety and affordability.
RFamide-related peptide (RFRP) is a homologous neuropeptide to gonadotropin-inhibitory hormone (GnIH), which is a hypothalamic neuropeptide that negatively regulates the hypothalamic-pituitary-gonadal axis. RFRP/GnIH is thought to be the mediator of stress because various stressors increase RFRP/GnIH mRNA expression and/or RFRP/GnIH neuronal activities. RFRP/GnIH may also directly regulate behavior, because RFRP/GnIH neuronal fibers and RFRP/GnIH receptor are widely expressed in the brain.
View Article and Find Full Text PDFEditorial: Recent Progress and Perspectives in Neurosteroid Research.
Front Endocrinol (Lausanne)
August 2022
Neurosteroids are steroids synthesized within the central nervous system either from cholesterol or by metabolic reactions of circulating steroid hormone precursors. It has been suggested that neurosteroids exert pleiotropic activities within the central nervous system, such as organization and activation of the central nervous system and behavioral regulation. It is also increasingly becoming clear that neuropeptides exert pleiotropic activities within the central nervous system, such as modulation of neuronal functions and regulation of behavior, besides traditional neuroendocrinological functions.
View Article and Find Full Text PDF