Publications by authors named "T Tzanov"
Article Synopsis
- Wearing contact lenses can lead to bacterial infections, which may cause serious complications and vision issues due to tear proteins allowing bacteria to stick.
- A promising solution involves using HA-ADH-Co nanogels as an antimicrobial coating for contact lenses, which reduces protein adsorption by up to 60% and effectively kills bacteria like Staphylococcus aureus and Pseudomonas aeruginosa.
- The nanogel coating maintains the lenses' optical performance and light transmission while improving comfort through better wettability, showing over 95% cell viability in safety tests.
Bacteriophages have gained significant interest as a potential solution to combat harmful bacteria, especially in the fight against antimicrobial resistance. With the rise in drug-resistant microorganisms, the medical community is increasingly exploring new alternatives to traditional antibiotics, and bacteriophages offer several advantages in this regard. However, phage applications still face some challenges, such as host specificity.
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- Four novel strains resistant to copper were tested against newly synthesized copper oxide nanoparticles (CuO and CuO NPs).
- Characterization methods confirmed the successful creation of these nanoparticles, which showed superiority in inhibiting bacterial growth due to their ability to induce oxidative stress.
- The study highlighted that CuO NPs not only reduced biofilm formation in copper-resistant strains but also revealed different responses based on the bacterial species, demonstrating the potential of nanotechnology in addressing metal tolerance in bacteria.
Purpose: Lignin is the most abundant source of aromatic biopolymers and has gained interest in industrial and biomedical applications due to the reported biocompatibility and defense provided against bacterial and fungal pathogens, besides antioxidant and UV-blocking properties. Especially in the form of nanoparticles (NPs), lignin may display also antioxidant and anti-inflammatory activities.
Methods: To evaluate these characteristics, sonochemically nano-formulated pristine lignin (LigNPs) and enzymatically-phenolated one (PheLigNPs) were used to expose zebrafish embryos, without chorion, at different concentrations.
Implant failure is primarily caused by poor osseointegration and bacterial colonization, which demands readmissions and revision surgeries to correct it. A novel approach involves engineering multifunctional interfaces using piezoelectric polyvinylidene fluoride (PVDF) materials, which mimic bone tissue's electroactive properties to promote bone integration and provide antibacterial functionality when mechanically stimulated. In this study, PVDF films were coated with antibacterial essential oil nanoparticles and antibiofilm enzymes using a layer-by-layer (LBL) approach to ensure antibacterial properties even without mechanical stimulation.
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