Publications by authors named "T Tuomi"
Article Synopsis
- * Data from a Swedish cohort study showed that individuals with ADs, particularly thyroid issues and inflammatory bowel disease, are more likely to develop LADA, with specific associations for those with higher autoantibody levels.
- * Although having ADs increases the risk of LADA, they do not seem to impact the likelihood of developing diabetic retinopathy when compared to type 2 diabetes.
Aims/hypothesis: Some studies find an increased risk of type 1 diabetes in children exposed to antibiotics. We investigated if exposure to antibiotics increases the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes.
Methods: We used data from a Swedish case-control study (Epidemiological Study of Risk Factors for LADA and Type 2 Diabetes [ESTRID]: LADA, n=597; type 2 diabetes, n=2065; control participants matched on participation time, n=2386) and a case-control study nested within the Norwegian Trøndelag Health Study (HUNT) (n=82/1279/2050).
Article Synopsis
- The study explores the genetic factors influencing β-cell function (BCF) and their relationship to type 2 diabetes (T2D), expanding on previous genetic research using large-scale data.
- By analyzing GWAS data from around 26,000 individuals, the researchers identified 55 unique genetic associations related to BCF traits derived from oral glucose tolerance tests.
- The findings reveal key genes that regulate insulin secretion and illustrate how different genetic mechanisms can affect T2D risk, offering a deeper understanding of the complex biology behind the disease.
Article Synopsis
- Genome-wide association studies have found numerous genetic loci linked to glycemic traits, but connecting these loci to specific genes and biological pathways remains a challenge.
- Researchers conducted meta-analyses of exome-array studies across four glycemic traits, analyzing data from over 144,000 participants, which led to the identification of coding variant associations in more than 60 genes.
- The study revealed significant pathways related to insulin secretion, zinc transport, and fatty acid metabolism, enhancing understanding of glycemic regulation and making data available for further research.
The high prevalence of autoimmune hypothyroidism (AIHT) - more than 5% in human populations - provides a unique opportunity to unlock the most complete picture to date of genetic loci that underlie systemic and organ-specific autoimmunity. Using a meta-analysis of 81,718 AIHT cases in FinnGen and the UK Biobank, we dissect associations along axes of thyroid dysfunction and autoimmunity. This largest-to-date scan of hypothyroidism identifies 418 independent associations (p < 5×10), more than half of which have not previously been documented in thyroid disease.
View Article and Find Full Text PDF