Publications by authors named "T Tsuruta"

Article Synopsis
  • Pancreatic cancer is highly aggressive with a 5-year survival rate under 10%, and cancer-associated fibroblasts (CAFs) play a crucial role in tumor growth and drug resistance.
  • The study found that coxsackievirus B3 (CVB3) effectively kills both pancreatic cancer cells and CAFs, showing its potential as a dual-action treatment.
  • CVB3 could be developed as a new oncolytic virotherapy, aiming to enhance drug sensitivity and improve outcomes for pancreatic cancer patients.
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Background: Spontaneous anterior interosseous nerve (AIN) palsy is characterized by the sudden onset of upper limb pain followed by weakness of muscles mainly innervated by the AIN. Although this palsy is conventionally treated conservatively, interfascicular neurolysis to release hourglass-like fascicular constrictions has been recommended. The present study aimed to establish the clinical characteristics and treatment strategy for this condition.

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A new xenicane diterpene named 4α-acetoxyisodictyohemiacetal (1) was isolated from the brown alga Dictyota coriacea, along with 11 known diterpenoids. The structure of 1 was established by spectroscopic analyses, and its absolute configuration was determined by comparing the experimental and theoretical electronic circular dichroism (ECD) spectra. Two dictyodiacetal diastereomers (5 and 6) were isolated and the full NMR assignments were performed.

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Objective: This case report presents a novel technique for bridge restoration using polytetrafluoroethylene (PTFE) tape and split dam isolation in situations where achieving complete dental dam isolation is challenging.

Clinical Considerations: Achieving high-quality isolation by controlling gingival crevicular fluid and intraoral relative humidity is important during cementation. However, an improved technique during bridge restoration is needed due to the difficulties faced with dental dam isolation.

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Immunoglobulin A (IgA) is a major gut antibody that coats commensal gut bacteria and contributes to shaping a stable gut bacterial composition. Although previous studies have shown that cyclic oligosaccharides, including cyclic nigerosyl-1,6-nigerose (CNN) and cyclodextrins (CDs, including αCD, βCD, and γCD), alter the gut bacterial composition, it remains unclear whether cyclic oligosaccharides modify the IgA coating of gut bacteria, which relates to cyclic oligosaccharide-induced alteration of the gut bacterial composition. To address this issue, mice were maintained for 12 weeks on diets containing CNN, αCD, βCD, or γCD; the animals' feces were evaluated for their bacterial composition and the IgA coating index (ICI), a measure of the degree of IgA coating of bacteria.

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