Publications by authors named "T Tsuruga"
BACKGROUND Pembrolizumab, a programmed cell-death protein-1 (PD-1)-targeting antibody, extends survival in cancer patients but may cause lung injury as a side effect. This immunotherapy enhances the immune system's ability to recognize and eliminate cancer cells. However, its immunomodulatory action can sometimes lead to immune-related adverse events, including lung injury.
View Article and Find Full Text PDFArticle Synopsis
- Ovarian clear cell carcinoma (OCCC) patients frequently experience thrombosis, which has been linked to worse prognoses in cancer generally, but its specific impact on OCCC outcomes was unclear.
- A study of 115 OCCC patients revealed that thrombosis occurred in 12.5% of early-stage and 42.8% of late-stage patients, significantly increasing the risk of poorer survival rates (e.g., 5-year progression-free survival was 20.6% for early-stage patients with thrombosis compared to 91.8% without).
- The findings indicate that thrombosis is more common in advanced OCCC stages and correlates with significantly worse prognosis across all stages, highlighting the need for closer monitoring
Background: Coagulopathy is a major cause of morbidity and mortality in COVID-19 patients. Hypercoagulability in COVID-19 results in deep vein thrombosis, thromboembolic complications, and diffuse intravascular coagulation. Microbiome dysbiosis influences the clinical course of COVID-19.
View Article and Find Full Text PDFArticle Synopsis
- - This study investigates the unique metabolic characteristics of ovarian clear cell carcinoma (CCC) by comparing it to normal tissues, specifically focusing on increased glutathione synthesis and its role in the cancer's development.
- - Evidence shows that CCC cells experience ferroptosis due to high levels of intracellular iron and lipid peroxides, which lead to cell death when glutathione synthesis is inhibited.
- - The use of a fluorescent imaging probe (gGlu-HMRG) successfully highlights differences in glutathione metabolism, displaying strong fluorescent signals in CCC tumor tissues, potentially aiding in distinguishing cancerous tissues from normal ones.
Bronchoscopy with radial-probe endobronchial ultrasound, a guide sheath, and electromagnetic navigation can improve the diagnostic yield of peripheral lung nodules. However, the suitability of specimens for genetic analysis remains unsatisfactory. We hypothesized that a transbronchial biopsy performed after closely approaching the bronchoscope tip to the lesion might provide more suitable specimens for genetic analysis.
View Article and Find Full Text PDF