Publications by authors named "T Trojan"
Article Synopsis
- - Mutations in the RAC2 protein are linked to various immune disorders in patients, including neonatal SCID and infantile diseases resembling leukocyte adhesion deficiency, with 15 new mutations identified among 54 patients studied.
- - The study highlighted that different types of mutations in RAC2 influenced disease outcomes; for instance, certain mutations led to neonatal SCID while others caused later-onset combined immune deficiency or LAD-like diseases.
- - Clinical analysis revealed significant immune system issues among affected patients, including low levels of T and B cells, recurrent infections, and abnormalities in neutrophil function, indicating severe impacts on their immune response.
Safety of subcutaneous immunotherapy in patients with severe asthma.
Ann Allergy Asthma Immunol
November 2022
Background: Severe asthma (SA) has been identified as a risk factor for severe systemic reactions (SR) to allergen subcutaneous immunotherapy (SCIT). However, the incidence and characterization of SRs in SA in comparison to less severe or no asthma is not known.
Objective: The objective of this study was to characterize the incidence of SRs in patients with SA receiving SCIT in comparison to patients with no asthma or less SA.
Background: Transforming Growth Factor-β (TGF-β) is a genetic modifier in patients with cystic fibrosis (CF). Several single nucleotide polymorphisms (SNPs) of TGF-β are associated with neutrophilic inflammation, lung fibrosis and loss of pulmonary function.
Aim: The aim of this study was to assess the relationship between genetic TGF-β polymorphisms and pulmonary disease progression in CF patients.
Article Synopsis
- The study looked at how a bacteria called Pa affects lung disease in people with cystic fibrosis (CF) by causing inflammation and scarring.
- Researchers measured different substances in the spit of CF patients to see how Pa infection changed things like inflammation and lung function.
- They found that Pa infection led to an imbalance in certain proteins, increased inflammation, and poorer lung function, suggesting that treating this inflammation could help CF patients in the future.
External apical root resorption and vectors of orthodontic tooth movement.
Am J Orthod Dentofacial Orthop
November 2020
Introduction: External apical root resorption is nearly ubiquitous in people treated orthodontically. This study predicted the extent of external apical root resorption by the vector of the incisor movement.
Methods: Cone-beam computed tomography scans of 93 white American adolescents (45 boys, 48 girls) with a Class I malocclusion who received comprehensive orthodontics were analyzed.