Publications by authors named "T Tretter"
The ability to measure students' engagement in an educational setting may facilitate timely intervention in both the learning and the teaching process in a variety of classroom settings. In this paper, a real-time automatic student engagement measure is proposed through investigating two of the main components of engagement: the behavioral engagement and the emotional engagement. A biometric sensor network (BSN) consisting of web cameras, a wall-mounted camera and a high-performance computing machine was designed to capture students' head poses, eye gaze, body movements, and facial emotions.
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- Crosstalk between synovial fibroblasts and immune cells is crucial in the development of rheumatoid arthritis, and the effectiveness of Janus kinase inhibitors (JAKi) varies among patients.
- The study evaluated the impact of three JAKi (tofacitinib, baricitinib, upadacitinib) on the interaction between synovial fibroblasts (SF) and T or B lymphocytes, finding that JAKi could suppress pro-inflammatory cytokines and enhance memory response of SF.
- The JAKi demonstrated both immunosuppressive and pro-inflammatory limiting effects on SF, with dose-dependent results that may explain the differing clinical responses to RA treatments, and some biologic DMARDs
Objective: Findings from recent transcriptome analyses of the synovium of patients with rheumatoid arthritis (RA) have revealed that 15-fold expanded HLA-DR+CD90+ synovial fibroblasts potentially act as key mediators of inflammation. The reasons for the expansion of HLA-DR+CD90+ synovial fibroblasts are unclear, but genetic signatures indicate that interferon-γ (IFNγ) plays a central role in the generation of this fibroblast subset. The present study was undertaken to investigate the generation, function and therapeutically intended blockage of HLA-DR+CD90+ synovial fibroblasts.
View Article and Find Full Text PDFBackground: A dysregulated glucose metabolism in synovial fibroblasts (SF) has been associated with their aggressive phenotype in rheumatoid arthritis (RA). Even though T helper (Th) cells are key effector cells in the propagation and exacerbation of synovitis in RA, little is known about their influence on the metabolism of SF. Thus, this study investigates the effect of Th cells on the glucose metabolism and phenotype of SF and how this is influenced by the blockade of cytokines, janus kinases (JAKs) and glycolysis.
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