Statins and immune-mediated necrotizing myopathy: Variability in the risk.

Introduction: Immune-mediated necrotizing myopathy (IMNM) is a form of statin myopathy characterized by the presence of antibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti HMGCR).

Objectives: The aim of this study was to investigate the relationship between the different statins and the risk of IMNM.

Methods: A two-time approach was used.

Drug-induced Sweet's syndrome: A case/non-case study in the French pharmacovigilance database.

Aims: Sweet's syndrome is an acute febrile neutrophilic dermatosis first described in 1964 by Robert Douglas Sweet. The pathophysiological mechanism is not fully established; however, several cases of Sweet's syndrome have been reported following drug administration.

Methods: To investigate the existence of pharmacovigilance signals between drugs and the occurrence of Sweet's syndrome, we performed a case/non-case study on reports of 'acute febrile neutrophilic dermatosis' registered in the French pharmacovigilance database.