Publications by authors named "T Traks"
Article Synopsis
- A study was conducted to investigate similarities and differences in protein expressions between psoriasis (PS) and atopic dermatitis (AD), using high-throughput mass spectrometry on skin samples from affected patients and healthy controls.
- The analysis revealed a significant overlap in proteomic profiles of PS and AD, indicating they share common pathogenesis mechanisms, while both differed from healthy skin.
- Notably, periostin (POSTN) was found to be highly expressed in AD but very low or absent in PS, suggesting its potential as a biomarker to distinguish between the two conditions.
Measurements of skin surface biomarkers have enormous value for the detailed assessment of skin conditions, both for clinical application and in skin care. The main goals of the current study were to assess whether expression patterns of skin surface hBD-1, hBD-2, IL-1α, CXCL-1, and CXCL-8, examples of proteins known to be involved in psoriasis pathology, are associated with disease severity and whether expression patterns of these proteins on the skin surface can be used to measure pharmacodynamic effects of biological therapy. In this observational study using transdermal analysis patch (TAP), levels of skin surface IL-1α, hBD-1, hBD-2, CXCL-1/2, and CXCL-8 of psoriasis vulgaris (PV) patients over biological therapy were assessed.
View Article and Find Full Text PDFPsoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including those targeted by effective therapies. However, the genetic liability to psoriasis is not fully explained by variation at robustly identified risk loci.
View Article and Find Full Text PDFBackground: Skin is a target organ and source of the corticotropin-releasing hormone-proopiomelanocortin (CRH-POMC) system, operating as a coordinator and executor of responses to stress. Environmental stress exacerbates and triggers inflammatory skin diseases through modifying the cellular components of the immune system supporting the importance of CRH-POMC system in the pathogenesis of psoriasis. The aim of this study was to analyse the association of CRH-POMC polymorphisms with psoriasis and evaluate transcript expression of lesional psoriatic and normal skin in RNA-seq data.
View Article and Find Full Text PDFArticle Synopsis
- Lichen planus is a chronic skin disease that may have similarities to conditions like psoriasis, and researchers aimed to better understand its underlying metabolic factors by comparing the blood of affected patients to that of healthy individuals.
- The study utilized high-throughput nuclear magnetic resonance (NMR) spectroscopy to analyze blood serum metabolites and lipoproteins.
- Significant changes were found in 16 markers related to lipoproteins, which could increase the risk of comorbidities like dyslipidemia and associated cardiovascular issues due to disturbed lipoprotein particle processing.