Publications by authors named "T Toyama"
Objective: Patients with chronic kidney disease (CKD) have an increased risk of adverse cardio-cerebrovascular events. The purpose of this study is to evaluate the prognostic predictors over 5 years in patients with CKD including haemodialysis.
Methods: In this multicenter, prospective cohort study performed with the Gunma-CKD SPECT Study protocol, 311 patients with CKD [estimated glomerular filtration rate (eGFR) < 60 min/ml/1.
Article Synopsis
- Minamata disease is a severe neurological disorder caused by methylmercury (MeHg) poisoning, identified in Japan in 1956, and previously thought to be linked to elevated selenium (Se) levels in patients.
- Research showed both mercury and selenium were present in historical samples from Minamata Bay, indicating that Se also contaminated the area and accumulated in patients' organs.
- The study's findings, including high Hg/Se molar ratios in brain tissue, help explain the neurological damage seen in patients and emphasize the dangers of consuming MeHg-contaminated seafood.
The relationship between D-AA metabolic enzymes and cancer development remains unclear. We aimed to investigate this relationship using mice deficient in D-AA-related metabolic enzymes. We examined mice lacking these enzymes for approximately 900 days and the effects of altered D-AA metabolism on cancer development based on lifespan, pathological findings, and gene expression.
View Article and Find Full Text PDFAim: While considerable data on the alcohol drinking behavior of the general population are available for the United States and Europe, data from Asian countries are scarce. We attempted to estimate the social backgrounds and other factors associated with high Alcohol Use Disorders Identification Test (AUDIT) scores in Japan.
Methods: This web-based survey was conducted in 2023.