Optimization of the process of acetylation and carboxymethylation for a polysaccharide from Gastrodia elata and antioxidant and immunomodulatory activities test.

A water-soluble polysaccharide extracted from Gastrodia elata was chemically modified to generate acetylated and carboxymethylated derivatives. Thourshe conditions for the two modification methods were optimized through single factor and response surface analyses. The optimized conditions for acetylation were 3.

Dynamic niche technology based hybrid breeding optimization algorithm for multimodal feature selection.

As a primary approach to address feature selection problems, evolutionary algorithms have been widely proposed to deal with the problem. Most of these methods are designed to find a single feature subset. However, the optimal feature subset within a dataset is often not unique, indicating that feature selection exhibits multimodal characteristics.

Adsorption and desorption of phenanthrene and 1-hydroxyphenanthrene by goethite-coated polyvinyl chloride.

Microplastics loaded with phenanthrene and derivatives are widely detected in aquatic environments, and the coating of natural minerals or organic macromolecules may change the environmental behavior of microplastics. In this study, three kinds of composites with different coverage were prepared by coating goethite on the surface of polyvinyl chloride microplastics to investigate the adsorption and desorption behavior of phenanthrene (PHE) and 1-hydroxyphenanthrene (1-OHPHE), and the effect of mucin on desorption was investigated. The results showed that goethite promoted the adsorption of PHE and 1-OHPHE by increasing the specific surface area of the composites.

Identification of Potent Leucine-Rich Repeat Kinase 2 Inhibitors by Virtual Screening and Biological Evaluation.

Parkinson's disease (PD) is the second most common neurodegenerative disease but has limited medications. Targeting leucine-rich repeat kinase 2 (LRRK2) has been identified as a potential strategy for the treatment of PD. The development of LRRK2 inhibitors has attracted much interest, and various compounds have been reported with significant improvement in preclinical and clinical models.

Effect of prednisone plus either adalimumab or cyclosporine on dermatological symptoms in Vogt-Koyanagi-Harada disease: systemic outcomes from a randomized trial.

Background: Vogt-Koyanagi-Harada (VKH) disease causes vitiligo, poliosis, and alopecia.

Objective: To investigate the effect of prednisone plus either adalimumab or cyclosporine-based immunosuppression on VKH dermatological disorders using ancillary data from a VKH eye disease trial.

Methods: Patients with VKH disease treated with individualized prednisone tapering (maximum daily dose, 40 mg; maximum duration, 6 months) were randomized to adjunctive adalimumab (N=54) or cyclosporine (N=56).