Publications by authors named "T Tonjum"
Functionalized regioisomers of the natural product phenazines myxin and iodinin as potent inhibitors of Mycobacterium tuberculosis and human acute myeloid leukemia cells.
Eur J Med Chem
January 2025
The natural bioactive products myxin and iodinin are phenazine 5,10-dioxides possessing potent anti-bacterial and anti-cancer activity in vitro. This work describes the synthesis and derivatization of new myxin and iodinin regioisomers, developed from 1,3-dihydroxyphenazine 5,10-dioxide. Compounds were evaluated for activity towards M.
View Article and Find Full Text PDFArticle Synopsis
- Human macrophages produce reactive nitrogen species in response to Mycobacterium tuberculosis infection, which causes stress in the bacteria and affects protein modifications.
- Researchers analyzed the acylation of Mtb proteins after exposure to low levels of nitric oxide, identifying 6,437 acylation events in 1,496 proteins, predominantly O-acylation.
- The study highlights how protein acylation may influence Mtb's responses to stress and antimicrobial resistance, marking the first comprehensive profiling of Mtb's acylation due to nitrosative stress, which could inform global health strategies.
() is a multidrug-resistant nontuberculous mycobacterium (NTM) that is responsible for a wide spectrum of infections in humans. The lack of effective bactericidal drugs and the formation of biofilm make its clinical treatment very difficult. The FDA-approved drug library containing 3048 marketed and pharmacopeial drugs or compounds was screened at 20 μM against type strain 19977 in 7H9 medium, and 62 hits with potential antimicrobial activity against were identified.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers developed new linezolid bioisosteres with a modified side chain to enhance effectiveness and lower toxicity.
- * One promising bioisostere showed better activity against certain resistant cells and was significantly less toxic than linezolid, indicating a safer treatment option.
A new class of structurally intriguing heterocycles embedded with spiropyrrolidine, oxindole and chromanones was prepared by regio- and stereoselectively in quantitative yields using an intermolecular tandem cycloaddition protocol. The compounds synthesized were assayed for their anti-mycobacterial activity against () H37Rv and isoniazid-resistant ( and promoter mutations) clinical isolates. Four compounds exhibited significant antimycobacterial activity against strains tested.
View Article and Find Full Text PDF