Publications by authors named "T Tomiya"
A 64-year-old man with cirrhosis was diagnosed with unresectable hepatocellular carcinoma and treated with a combination of durvalumab and tremelimumab. The patient had no history of diabetes mellitus. Three weeks later, the patient developed general fatigue, dry mouth, and polyuria.
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- * Out of 126 patients, 37.3% were found to have CHE, with low serum zinc levels being a significant predictor, while blood ammonia levels did not contribute to the risk.
- * The research emphasizes the importance of early zinc supplementation in cirrhotic patients, particularly those taking higher doses of furosemide, to prevent the progression to overt hepatic encephalopathy (OHE).
Article Synopsis
- The study analyzed 5804 days of Super-Kamiokande data from 1996 to 2018 to detect variations in solar ^{8}B neutrino flux.
- The researchers utilized a five-day interval measurement approach and employed maximum likelihood and Lomb-Scargle methods to find any periodic modulations.
- They found a significant modulation related to Earth's elliptical orbit around the Sun, with measurements of eccentricity and perihelion shift aligning with astronomical data.
Aim: Patients with chronic hepatitis B virus (HBV) infection experiencing viral breakthrough (BTH) or partial response (PR) during lamivudine (LAM) or entecavir hydrate (ETV) administration often took ETV plus tenofovir alafenamide fumarate (TAF) due to the emergence of a drug-resistance mutation. However, in patients lacking drug-resistance mutation against TAF, sufficient antiviral effects may be achievable with TAF monotherapy. We assessed the drug-resistance profile through nucleotide sequences of HBV pregenome RNA, and subsequently changed to TAF monotherapy from ETV plus TAF.
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