Publications by authors named "T Tolga Demirtas"
Article Synopsis
- - Ovarian cancer significantly contributes to cancer-related deaths in women, making early diagnosis and personalized medicine crucial to improving outcomes through new drug discovery methods.
- - The study utilized an integrated systems biology and machine learning approach to analyze multiple transcriptome datasets, identifying a significant gene module called "SOV-module" that consists of 19 genes associated with serous ovarian cancer.
- - The SOV-module showed impressive diagnostic accuracy of 96.7% sensitivity and 100% specificity, and 63% accuracy in prognostic predictions, underscoring its potential as a genomic biomarker for personalized treatment strategies in ovarian cancer.
Metal-organic frameworks (MOFs) have recently emerged as a useful class of nanostructures with well-suited characteristics for drug delivery applications, due to the high surface area and pore size for efficient loading. Despite their use as a nano-carrier for controlled delivery of various types of drugs, the inherent osteo-conductive properties have stolen a great attention as a growing area of investigation. Here, we evaluated the double function of UiO-66 MOF structure as a carrier for fosfomycin antibiotic and also as an osteogenic differentiation promoter when introduced in 3D chitosan scaffolds, for the first time.
View Article and Find Full Text PDFAim: This study aimed to present the short- and long-term results of Demirtas two-step treatment model in patients with obstructed-hydronephrotic kidneys functioning below 10%, and before deciding on nephrectomy, to evaluate whether this method can contribute to the accurate assessment.
Material And Methods: This prospective study included patients with unilateral renal obstruction and renal parenchymal loss assessed by computed tomography and whose renal function was found to be below 10% in Tc-99m-dimercaptosuccinic acid. In the first step, percutaneous nephrostomy (PCN) was performed.
Article Synopsis
- * Despite their minimally invasive nature, these traditional methods still involve some level of invasiveness.
- * The report highlights a new "zero-incision" technique called Natural Orifice Transurethral Endoscopic Vesicovaginal Fistula (NOTE-VVF), which repairs VVF by using the urethra as a natural access point for the laparoscopic trocar.
Objective Endoscopic enucleation of the prostate has evolved and became popular for the surgical treatment of benign prostatic hyperplasia (BPH) during the last decade. Different surgical techniques have been described so far. We hereby described a new modified two-lobe technique for urologists who are inexperienced in endoscopic enucleation.
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