Publications by authors named "T Tichler"
Purpose: SIRFLOX was a randomized, multicenter trial designed to assess the efficacy and safety of adding selective internal radiation therapy (SIRT) using yttrium-90 resin microspheres to standard fluorouracil, leucovorin, and oxaliplatin (FOLFOX)-based chemotherapy in patients with previously untreated metastatic colorectal cancer.
Patients And Methods: Chemotherapy-naïve patients with liver metastases plus or minus limited extrahepatic metastases were randomly assigned to receive either modified FOLFOX (mFOLFOX6; control) or mFOLFOX6 plus SIRT (SIRT) plus or minus bevacizumab. The primary end point was progression-free survival (PFS) at any site as assessed by independent centralized radiology review blinded to study arm.
Article Synopsis
- Intravenous silibinin (SIL) combined with ribavirin (RBV) was tested as an interferon-free treatment for a patient with hepatitis C, focusing on its safety, effectiveness, and the use of mathematical modeling in determining treatment duration.
- The treatment resulted in a sustained virological response (SVR) after 34 weeks, confirming the feasibility and safety of this regimen.
- This study highlights the potential of using real-time mathematical modeling for tailoring treatment duration and involves patients in decision-making regarding their therapy.
Background: The specialty and practice of internal medicine have been subject to serious challenges in the last two decades.
Methods: We describe the integrative model of internal medicine as developed in our hospital, providing solutions to some major challenges.
Results: Major components include: (1) Senior physicians and residents are employed by the Division rather than individual Departments of Medicine, allowing for balanced distribution of professional capabilities.
Aims And Background: To analyze the efficacy and toxicity of adjuvant chemotherapy followed by whole abdominal irradiation in the treatment of resectable gastric cancer with positive lymph nodes.
Methods And Study Design: Between 1996 and 1999, 10 patients with node-positive gastric cancer underwent complete gross resection and were treated by postoperative chemoradiotherapy. The chemotherapy regimen consisted of 5-fluorouracil, 1000 mg/m2/day as a 96-hr continuous infusion on day 1, and cisplatin, 100 mg/m2 on day 2, every 21 days.
Article Synopsis
- Summarizes the study's aim of testing a combination chemotherapy regimen of 5-FU, leucovorin, and cisplatin in patients with advanced gastric cancer.
- The study involved 45 previously untreated patients, with two dose levels of treatment, noting that most patients tolerated the regimen well despite some experiencing significant toxicity.
- Findings indicated a partial response rate of 33% and stable disease in 28%, suggesting this regimen may be as effective as more complex treatments while offering manageable safety concerns.