Publications by authors named "T Thome"
Purpose: Physical activity (PA) guidelines suggest a link between PA, sedentary time, and sleep quality (SQ). Step cadence is an emerging proxy for PA intensity, with zero cadence (ZC) indicating sedentary time. No research has explored the relationship between ZC and SQ.
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- Chronic kidney disease (CKD) leads to the buildup of toxic metabolites that negatively impact skeletal muscle, specifically through activation of the aryl hydrocarbon receptor (AHR).
- In patients and mice with CKD, AHR-dependent genes were found to be upregulated in skeletal muscle, and increased AHR activation was linked to impaired mitochondrial function and respiration.
- Muscle-specific deletion of the AHR improved mitochondrial function, revealing a uremic metabolite/AHR/Pdk4 axis that influences mitochondrial energy production in skeletal muscle during CKD.
Background: Accumulating evidence has demonstrated that chronic tobacco smoking directly contributes to skeletal muscle dysfunction independent of its pathological impact to the cardiorespiratory systems. The mechanisms underlying tobacco smoke toxicity in skeletal muscle are not fully resolved. In this study, the role of the aryl hydrocarbon receptor (AHR), a transcription factor known to be activated with tobacco smoke, was investigated.
View Article and Find Full Text PDFExertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression, and impaired satellite cell function in mice.
Am J Physiol Regul Integr Comp Physiol
February 2024
The effect of exertional heat stroke (EHS) exposure on skeletal muscles is incompletely understood. Muscle weakness is an early symptom of EHS but is not considered a major target of multiorgan injury. Previously, in a preclinical mouse model of EHS, we observed the vulnerability of limb muscles to a second EHS exposure, suggesting hidden processes contributing to declines in muscle resilience.
View Article and Find Full Text PDFBackground: Lower extremity peripheral artery disease (PAD) is a growing epidemic with limited effective treatment options. Here, we provide a single-nuclei atlas of PAD limb muscle to facilitate a better understanding of the composition of cells and transcriptional differences that comprise the diseased limb muscle.
Methods: We obtained gastrocnemius muscle specimens from 20 patients with PAD and 12 non-PAD controls.