NLRP3 Inflammasome Activation and Altered Mitophagy Are Key Pathways in Inclusion Body Myositis.

Background: Inclusion body myositis (IBM) is the most prevalent muscle disease in adults for which no current treatment exists. The pathogenesis of IBM remains poorly defined. In this study, we aimed to explore the interplay between inflammation and mitochondrial dysfunction in IBM.

Detection of decline in estimated glomerular filtration rate in patients with type 2 diabetes by cystatin C-based equations.

Background: Aging population is a significant issue in Viet Nam and across the globe. Elderly individuals are at higher risk of chronic kidney disease (CKD), especially those with diabetes. Several studies found that the estimated glomerular filtration rate (eGFR) determined using creatinine-based equations was not as accurate as that determined using cystatin C-based equations.

Whole-genome sequence of Pseudomonas sp. strain HOU2 isolated from dangshen (Codonopsis javanica) roots.

Objectives: This study aims to generate a de novo complete whole-genome assembly of Pseudomonas sp. strain HOU2, which is an endophytic bacterium isolated from dangshen roots that shows to improve the growth of in vitro dangshen plants. Further investigation of the whole genome of Pseudomonas sp.

synthesis of gold nanoparticles embedded in a magnetic nanocomposite of glucosamine/alginate for enhancing recyclable catalysis performance of nitrophenol reduction.

In this study, we introduce an synthesis technique for incorporating gold nanoparticles (AuNPs) into a magnetic nanocomposite made of glucosamine and alginate (GluN/Alg) ionotropic gelation. GluN acted as a reducing agent for gold ions, leading to the formation of AuNPs which embedded in the nanocomposite FeO@GluN/Alg. Analytical techniques confirmed the crystallite structure of the nanocomposite AuNPs/FeO@GluN/Alg, which had an average size of 30-40 nm.

Case Report: A novel hemizygous missense variant in a Vietnamese boy with pyruvate dehydrogenase E1-alpha deficiency.

A pyruvate dehydrogenase complex deficiency causes a reduction in adenosine triphosphate production and energy insufficiency, leading to neurological disorders. An abnormal E1-alpha protein originating from the gene with pathogenic variants is unable to communicate with E1-beta for the formation of the E1 enzyme, decreasing pyruvate dehydrogenase complex activity. In this study, we report a Vietnamese boy with lethargy, severe metabolic acidosis, increased serum lactate, hyperalaninemia, lactic acidosis, and globus pallidus lesions.