Publications by authors named "T Tetsuka"
Article Synopsis
- A nationwide surveillance study in Japan assessed the antimicrobial susceptibility of bacterial pathogens related to respiratory tract infections, collecting data from June 2019 to December 2020.
- The study analyzed 932 bacterial strains from 32 medical facilities, finding notable resistance rates, such as 35.3% for methicillin-resistant Staphylococcus aureus and 16.2% for β-lactamase-producing resistant Haemophilus influenzae.
- Results from this surveillance aim to inform treatment strategies for respiratory infections in Japan and promote the responsible use of antimicrobial drugs.
Purpose: The extent of effectiveness of upfront androgen receptor-axis-targeted therapies (ARAT) versus total androgen blockade (TAB) in improving prostate cancer-specific survival (CSS) and progression-free survival (PFS) in a real-world sample of Japanese patients with high-volume mHSPC remains unclear. We, therefore, investigated the efficacy and safety of upfront ARAT versus bicalutamide for de novo high-volume mHSPC in Japanese patients.
Material And Methods: This was a multicenter retrospective study that analyzed CSS, clinical PFS, and adverse events (AEs) in 170 patients with newly diagnosed high-volume mHSPC.
We herein report a 58-year-old Japanese woman who survived 14 years after surgery for lung adenocarcinoma harboring an epidermal growth factor receptor (EGFR) exon 19 deletion. She developed recurrence, for which she underwent multimodal therapy, including EGFR-tyrosine kinase inhibitor (TKI) administration. She ultimately died from a rapidly progressive right lung tumor that was resistant to EGFR-TKI.
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- Nursing and healthcare-associated pneumonia (NHCAP) is a specific type of pneumonia that has customized guidelines for Japan, which face challenges in severity classification.
- A study involving 303 patients from Niigata General City Hospital compared the effectiveness of various pneumonia severity classifications (A-DROP, CURB-65, PSI, I-ROAD) in predicting patient outcomes.
- Results showed that both 30-day and in-hospital mortality rates tended to rise with increasing severity levels, indicating that A-DROP was particularly useful in anticipating the prognosis for patients with NHCAP.
Protein-carbohydrate interactions exhibit myriad intracellular recognition events, so understanding and investigating their specific interaction with high selectivity and strength are of crucial importance. In order to examine the effect of multivalent binding on the specificity of protein-carbohydrate interactions, we synthesized mannose glycosides as a novel type of glycosylated monomer and glycopolymers of polyacrylamide derivatives with α-mannose (α-Man) by radical polymerization and monitored their strength of interaction with concanavalin A (Con A) by surface plasmon resonance (SPR) detection. In a quantitative test using the Con A-immobilized sensor surface, the kinetic affinity for the synthesized polymers, ( = 3.
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