Publications by authors named "T Tatsukawa"
Marine mammals possess a specific subcutaneous fat layer called blubber that not only insulates and stores energy but also secretes bioactive substances. However, our understanding of its role as a secretory organ in cetaceans is incomplete. To exhaustively explore the hormone-like substances produced in dolphin subcutaneous adipose tissue, we performed seasonal blubber biopsies from captive female common bottlenose dolphins (Tursiops truncatus; N = 8, n = 32) and analyzed gene expression via transcriptomics.
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- The Indigo Aspiration System is a catheter-based device designed for removing clots in peripheral arteries and veins, recently launched in Japan for treating acute limb ischemia.
- The first use of this system involved a 96-year-old man suffering from acute lower limb ischemia due to an embolism related to a left common iliac artery aneurysm.
- The treatment resulted in a notable improvement in blood flow to the patient's left foot, highlighting the device's effectiveness and relevant use cases.
Cortisol is secreted from the adrenal cortex in response to stress, and its circulating levels are used as robust physiological indicators of stress intensity in various animals. Cortisol is also produced locally in adipose tissue by the conversion of steroid hormones such as cortisone, which is related to fat accumulation. Circulating cortisol levels, probably induced by cold stress, increase in cetaceans under cold conditions.
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- - Increased lactate levels from glycolysis are being studied as potential markers for metabolic changes in neurons, linked to a drop in brain pH, which has been associated with various neuropsychiatric disorders like schizophrenia and autism.
- - Research shows that these pH and lactate changes are common across different animal models, including those for depression, epilepsy, and Alzheimer's disease, though findings vary, particularly within the autism spectrum.
- - A large-scale analysis indicated that higher lactate levels correlate with worse working memory performance, suggesting that altered brain chemistry might reflect underlying conditions across multiple disorders.
Background: Skeletal muscle comprises almost 40% of the human body and is essential for movement, structural support and metabolic homeostasis. Size of multinuclear skeletal muscle is stably maintained under steady conditions with the sporadic fusion of newly produced myocytes to compensate for the muscular turnover caused by daily wear and tear. It is becoming clear that microvascular pericytes (PCs) exhibit myogenic activity.
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