Publications by authors named "T Taouil"
Background: In Martinique, prostate cancer (Pca) incidence rates are nowadays among the highest worldwide with a high incidence of early-onset and familial forms. Despite the demonstration of a strong familial component, identification of the genetic basis for hereditary Pca is challenging. The HOXB13 germline variant G84E (rs138213197) was described in men of European descent with Pca risk.
View Article and Find Full Text PDFBackground: There are no comparative data on pathological predictors at diagnosis, between African Caribbean and Caucasian men with prostate cancer (PCa), in equal-access centers. The objective of this study was to evaluate the grade groups of an African Caribbean cohort, newly diagnosed with PCa on prostate biopsy, compared with a Caucasian French Metropolitan cohort.
Methods: A retrospective, a comparative study was conducted between 2008 and 2016 between the University Hospital of Martinique in the French Caribbean West Indies, and the Saint Joseph Hospital in Paris.
Article Synopsis
- Prostate cancer is highly prevalent among African-Caribbean men, and the study analyzed biochemical outcomes of brachytherapy treatment in this demographic from 2005 to 2014.
- Three hundred seventy patients with localized, primarily low-risk prostate cancer were included, and the study demonstrated impressive 3-year and 5-year biochemical failure-free survival rates of 98.3% and 91.6%, respectively.
- Brachytherapy proved to be an effective treatment option with low rates of significant genitourinary toxicity, making it a viable choice for managing localized prostate cancer in African-Caribbean patients.
Article Synopsis
- Prostate cancer rates are particularly high in the African-Caribbean population, prompting this study to investigate PSA changes after brachytherapy.
- From 2005 to 2013, 371 patients underwent brachytherapy with strict eligibility criteria, and PSA variability was monitored post-treatment.
- Findings revealed that after a median follow-up of 50 months, over half of the patients showed continuous decline in PSA, while 31% experienced a PSA bounce, which occurred approximately 12 months post-brachytherapy and was notably linked to younger age and higher immediate post-treatment PSA levels.