Publications by authors named "T Takayama"
In molecular dynamics (MD) simulations of water, rigid non-polarizable models are still valuable and widely used because of their low computational cost and excellent performance. Most of such models have been for light water (H2O) for a long time, and a few have recently been reported for heavy water (D2O). The specific models of D2O are needed because of its notably slower dynamics and stronger hydrogen bond than H2O.
View Article and Find Full Text PDFPurpose: Pyrrolidinophenone derivatives (PPs) are amphetamine-like designer drugs containing a pyrrolidine ring, and their adverse effects resemble those of methamphetamine (METH). Microglial activation has been recently suggested as a key event in eliciting the adverse effects against dysfunction of the central nervous system. The aim of this study is to clarify the mechanisms of microglial activation induced by PPs.
View Article and Find Full Text PDFBackground: There is no clinically relevant serological marker for the early detection of oesophageal adenocarcinoma (EAC) and its precursor lesion, Barrett's oesophagus (BE).
Objective: To develop and test a blood-based assay for EAC and BE.
Design: Oesophageal MicroRNAs of BaRRett, Adenocarcinoma and Dysplasia () was a large, international, multicentre biomarker cohort study involving 792 patient samples from 4 countries (NCT06381583) to develop and validate a circulating miRNA signature for the early detection of EAC and high-risk BE.
Article Synopsis
- Gallibacterium anatis and Enterococcus cecorum are bacteria linked to opportunistic infections in poultry and occasionally cause infections in immunocompromised individuals from contaminated food.
- A 78-year-old Japanese man with acute cholangitis was found to have a coinfection of these bacteria, which were identified as highly virulent and multidrug-resistant strains through genome sequencing.
- The case highlights that a common bile duct stone can pose a risk for infections by these pathogens even in healthy individuals, underscoring the need for monitoring these bacteria in animals and understanding their effects on human health.