Epidemiology of syphilis in Hungary between 1952 and 1996.

Trends in morbidity from syphilis in Hungary between 1952 and 1996 were analysed. The incidence of syphilis/100,000 inhabitants declined rapidly owing to the public health and therapeutic measures of the early 1950s (1952: total=73.6, early infections=60.

[HIV seropositivity in promiscuous heterosexual, homosexual and bisexual men and patients voluntarily reporting for screening in Hungary between 1 January 1986 and 31 December 1989].

The cumulative seroprevalence was 5.21% among the homo/bisexual men in the four years. As well as in Budapest, we experienced the increase of seroprevalence in the country, too, after a decrease in 1988.

Analytical studies on the hydrolysis of Chinoin-102 and Chinoin-127, candidate compounds for stability studies.

The isolation and structural elucidation of some products of hydrolytic studies with two drugs, Chinoin-102 and Chinoin-127, are described. CH-127 is 1,6(ax)-dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido-[1,2-a]-pyrimidine-3-carboxamide. CH-102 is 8,9-dimethoxy-3-imino-5,6-dihydro-3H-thiazolo-[4,3-a]-isoquinoline-1-carbonitrile.