Publications by authors named "T Tagawa"
Kaposi sarcoma herpesvirus (KSHV) is an oncogenic DNA virus associated with various malignancies, including tumours like Kaposi sarcoma and Primary effusion lymphoma. Recently, the importance of the tumour microenvironment in KSHV-associated tumours is being studied. New studies utilizing human primary cells, co-culture experiments with KSHV-infected cells, and modern techniques like time-resolved single cell analysis, have significantly advanced the understanding of KSHV interactions with monocytes and macrophages.
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- * The research analyzed changes in lymphocyte distributions in KS tissues through a computational method that compares transcriptome data with immune cell RNA expression patterns.
- * Findings indicated that cytokines and chemokines from KSHV-infected cells could influence the tissue environment, promoting the differentiation of macrophages to a proinflammatory state in culture assays.
Article Synopsis
- Kaposi sarcoma (KS) is a cancer linked to abnormal blood vessel growth, primarily caused by the Kaposi sarcoma herpesvirus (KSHV) found in specialized tumor cells.
- Researchers have developed a method to grow patient-derived KS tumors in mice, allowing them to maintain the KSHV infection and tumor characteristics for extended periods, which is crucial for studying the disease.
- The study found that the resulting tumors displayed increased density of KSHV-infected cells, higher proliferation rates, and maintained gene expressions associated with KS, indicating that these mouse models can help in understanding the disease and testing new treatments.
Black ginger () extract (KPE) is extracted from a ginger family plant grown in Thailand. The polyphenolic components have potential antioxidant effects and have been reported to enhance exercise performance. However, the impact of long-term KPE administration combined with long-term training on the endurance exercise performance of healthy individuals has not been fully studied.
View Article and Find Full Text PDF3-(4-Hydroxy-3-methoxyphenyl)propionic acid (HMPA), also known as dihydroferulic acid, is a hydroxycinnamic acid derivative that can be derived from the microbial transformation of dietary polyphenols or naturally obtained from fermented foods. Although numerous studies have documented its antioxidant and anti-obesity effects, the effect of HMPA on muscle function remains unknown. This study investigated the effects of HMPA on muscle strength and exercise endurance capacity.
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