Publications by authors named "T T Valiev"
Article Synopsis
- Metastatic colorectal cancer has a low 5-year survival rate of under 15%, with common metastasis sites being the lungs and liver, while skin metastases are rare and often indicate a worse prognosis.
- A case study of a 62-year-old woman revealed skin metastases from rectal cancer developed two years after treatment, confirming these through histological examination, although differing mutations were found between the primary tumor and skin lesions.
- Despite treatment with FOLFOX6 chemotherapy and bevacizumab, the therapy failed, highlighting the need for close monitoring of skin for metastases in rectal cancer patients, as literature suggests median survival after detection is only 8.5 months.
Article Synopsis
- Diagnosing skin diseases in children is complex, and Incontinentia pigmenti (IP) is a rare hereditary condition that can lead to serious complications like squamous cell carcinoma (SCC) in young patients.
- A case study involving a 10-year-old girl with IP highlights the importance of an interdisciplinary approach, with input from multiple specialists including dermatologists, geneticists, and oncologists.
- Genetic evaluations confirmed a mutation in the gene responsible for IP in the family, leading to successful treatment over a 2-year period, while also revealing varied symptoms among affected family members.
Lymphoid tumors with testicular involvement in childhood are rare and heterogeneous. The disease may manifest with uni- or bilateral scrotal enlargement. Comprehensive examination includes evaluation of all lymph nodes involvement, as well as ultrasound examination, magnetic resonance imaging and positron emission tomography.
View Article and Find Full Text PDFThis review is focused on synephrine, the principal phytochemical found in bitter orange and other medicinal plants and widely used as a dietary supplement for weight loss/body fat reduction. We examine different aspects of synephrine biology, delving into its established and potential molecular targets, as well as its mechanisms of action. We present an overview of the origin, chemical composition, receptors, and pharmacological properties of synephrine, including its anti-inflammatory and anti-cancer activity in various in vitro and animal models.
View Article and Find Full Text PDFObjectives: To evaluate the role of ABCB1 (C3435T rs1045642, rs1128503, rs2032582, rs4148738), SLCO1B1 T521C rs4149056 genetic polymorphisms in the development of major types of methotrexate (MTX) toxicities and the occurrence of a terminal event (death, relapse) in pediatric АLL.
Methods: The study included 124 patients diagnosed with pediatric ALL. All patients treated according to the protocols of the German BFM group (2002/2009) with high-dose (1,000, 2,000 and 5,000 mg/m) methotrexate.