[Necrotic leg ulcers induced by vitamin K antagonists: five cases].

Background: Vitamin K antagonists (VKAs) are widely used in thromboembolic diseases. We report five cases of necrotic leg ulcers having a particularly severe course and in which withdrawal of VKA treatment alone enabled healing.

Case Reports: Five patients presented with necrotic leg ulcers clinically evocative of necrotic angiodermatitis or vasculitis.

[Polymorphic eruption of pregnancy and acquired hemophilia A].

Background: Acquired haemophilia A (AHA) is a rare and serious disease, and instances of association with skin diseases have been described. We report a case of postpartum AHA associated with atypical polymorphic eruption of pregnancy (PEP).

Patients And Methods: Following delivery of her second child, a 27-year-old woman developed a generalised pruritic erythematous papular and vesicular rash in plaques.

Usefulness of skin testing in cutaneous drug eruptions in routine practice.

Background: Cutaneous drug eruptions are common side-effects. The imputation score combining intrinsic (chronology, clinical and paraclinical signs) and extrinsic criteria used in Pharmacovigilance Centres is insufficient alone to identify with certainty a responsible drug.

Objective: To evaluate the imputation score before and after performing skin testing in patients with cutaneous drug eruptions.

[Efficacy of rituximab in a case of refractory bullous pemphigoid].

Background: The mainstay in the treatment of bullous pemphigoid (BP) is corticosteroids. Immunosuppressive agents might be used for steroid-sparing effect. We report the case of a patient with refractory BP successfully treated with rituximab.

Long-term survivors in stage IV melanoma: a regional population-based study in France.

We aimed to better characterize exceptional cases of long survivors (LSs) among patients with stage IV melanoma. We performed a comprehensive regional investigation in the Champagne-Ardenne region, France. During the period 1994-2003, 316 patients died of melanoma whereas 10 patients diagnosed with distant metastases had a subsequent survival time > 4 years.