Mitochondrial Integrity Is Critical in Right Heart Failure Development.

Molecular processes underlying right ventricular (RV) dysfunction (RVD) and right heart failure (RHF) need to be understood to develop tailored therapies for the abatement of mortality of a growing patient population. Today, the armament to combat RHF is poor, despite the advancing identification of pathomechanistic processes. Mitochondrial dysfunction implying diminished energy yield, the enhanced release of reactive oxygen species, and inefficient substrate metabolism emerges as a potentially significant cardiomyocyte subcellular protagonist in RHF development.

Influence of caries activity and number of saliva donors: mineral and microbiological responses in a microcosm biofilm model.

Objective: this study evaluated the mineral and microbiological response of biofilms originating from different types of saliva inoculum with distinct levels of caries activity.

Methodology: the biofilms grown over enamel specimens originated from saliva collected from a single donor or five donors with two distinct levels of caries activity (caries-active and caries-free) or from pooling saliva from ten donors (five caries-active and five caries-free). The percentage surface hardness change (%SHC) and microbiological counts served as outcome variables.

Effect of ionizing radiation and cariogenic biofilm challenge on root-dentin caries.

Objectives: To evaluate the effect of ionizing radiation and cariogenic biofilm challenge using two continuous flow models, normal and reduced salivary flow, on the development of initial root-dentin caries lesions.

Materials And Methods: Microcosm biofilms were grown under two salivary flow rates (0.06 and 0.

Influence of biofilm removal from the tooth-restoration interface on the progression of secondary caries lesions: a preliminary model study.

This study investigated the effects of biofilm removal from the tooth-restoration surface on secondary caries lesion progression. Biofilms were grown for up to 28days on resin-restored enamel-dentin disks with an interfacial gap with DMM or DMM+1% sucrose under five different protocols of Visible Biofilm Removal (V-BR; n=7): (1) without V-BR, (2) with partial V-BR, (3) with total V-BR, (4) with total V-BR and saliva reinoculation, and (5) without V-BR under 9h of cariogenic challenge. V-BR was performed at 7, 14 and 21days.

Aging Reduces the Anticaries Effect of Antibacterial Adhesive - An In Vitro Biofilm Study.

Purpose: This in vitro study investigated whether aging different restorative materials influences secondary caries development using a short-term in vitro biofilm model, hypothesizing that the antibacterial adhesive employed may lose its effect over time.

Materials And Methods: Sixty enamel-dentin blocks were divided into 6 groups with n = 10 per group. The groups were restored with three different restorative materials, of which each sample contained an artificial gap: composite with conventional adhesive (CCA; negative control), composite with an antibacterial adhesive (CAA), and amalgam (A; positive control).