The need for better metrics for floor-tile topography: Conventional metrics correlate only modestly with shoe-floor friction.

Roughness metrics measured with stylus profilometry are commonly used to explain a floor's friction performance, yet these metrics inconsistently predict shoe-floor friction. While strong correlations have been shown for systematically modified flooring, the goal of this study is to address a gap regarding the predictive ability of these metrics across heterogeneous porcelain flooring products. The predictive ability of four roughness metrics on oily friction performance was assessed using 23 floors and 4 shoe designs.

Patient Positional Uncertainty and Margin Reduction in Lung Stereotactic Ablative Radiation Therapy Using Pneumatic Abdominal Compression.

Purpose: Motion management presents a significant challenge in thoracic stereotactic ablative radiation therapy (SABR). Currently, a 5.0-mm standard planning target volume (PTV) margin is widely used to ensure adequate dose to the tumor.

Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome.

The NLRP3 inflammasome plays a pivotal role in host defense and drives inflammation against microbial threats, crystals, and danger-associated molecular patterns (DAMPs). Dysregulation of NLRP3 activity is associated with various human diseases, making it an attractive therapeutic target. Patients with NLRP3 mutations suffer from Cryopyrin-Associated Periodic Syndrome (CAPS) emphasizing the clinical significance of modulating NLRP3.

Distinct brain and lung endothelial miRNA/mRNA profiles after exposure to infected red blood cells.

MicroRNAs (miRNAs) control 60% of genes expressed in the human body, but their role in malaria pathogenesis is incompletely understood. Here, we demonstrate cell type-specific alterations to the miRNA profiles during the early response to malaria infection in brain and lung endothelial cells (ECs). In brain ECs, incubation with -infected red blood cells in the ring stage (iRBCs) most significantly affected endocytosis-related miRNAs and mRNAs.