[Expertise of anthropometric indicators of children and adolescents of the Nizhny Novgorod Region in 1944/45-1959/60-2019/22].

Objective: To analyze the main anthropometric indicator - body length of children and adolescents - with a view to applying the current regional standard in the practice of forensic medical examinations in the constituent entity of the Volga Federal District.

Material And Methods: Analysis of retrospective regional standards of the «body length» anthropometric indicator in 218 109 children and adolescents in 1944/45 and 1959/60, biometric systematics of the indicator for the modern population of children and adolescents aged 7-17 years (11 392 cases) in the Nizhny Novgorod Region were performed.

Results: Significant increases in the indicators of body length have been found in all age-sex groups.

Palmoplantar Keratoderma: A Molecular Genetic Analysis of Family Cases.

Palmoplantar keratoderma is a clinically polymorphic disorder with a heterogeneous etiology characterized by marked hyperkeratotic lesions on the surface of palms and soles. Hereditary forms of palmoplantar keratoderma usually have autosomal dominant inheritance and are caused by mutations in dozens of genes, most of which belong to the keratin family. We carried out clinical and molecular genetic analysis of the affected and healthy members of four families with autosomal dominant palmoplantar keratoderma.

[Nutritional status of preschool children of Moscow megalopolis at the beginning of the 21st century (somatometric aspects)].

Obesity is one of the most important and actual problems of public health, of healthcare, which dramatically expanded through the latest four decades. of the study was the analysis of physical conditions of Moscow preschoolers at the beginning of 21th century as the indicator of nutritional status in «obesogenic» environment of megalopolis. .

Nuclear envelope-localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis.

Deciphering novel pathways regulating liver lipid content has profound implications for understanding the pathophysiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Recent evidence suggests that the nuclear envelope is a site of regulation of lipid metabolism but there is limited appreciation of the responsible mechanisms and molecular components within this organelle. We showed that conditional hepatocyte deletion of the inner nuclear membrane protein lamina-associated polypeptide 1 (LAP1) caused defective VLDL secretion and steatosis, including intranuclear lipid accumulation.

Towards sustainable diagnostics: replacing unstable HO by photoactive TiO in testing systems for visible and tangible diagnostics for use by blind people.

Blind and color blind people cannot use colorimetric diagnostics; the problem is especially severe in rural areas where high temperatures and the absence of electricity challenge modern diagnostics. Here we propose to replace the unstable component of a diagnostic test, HO, with stable TiO. Under UV irradiation, TiO forms reactive oxygen species that initiate polymerization of acrylamide causing liquid-to-gel transition in an analyte-dependent manner.