Publications by authors named "T Syversveen"
Objectives: Total tumor volume (TTV) is associated with overall and recurrence-free survival in patients with colorectal cancer liver metastases (CRLM). However, the labor-intensive nature of such manual assessments has hampered the clinical adoption of TTV as an imaging biomarker. This study aimed to develop and externally evaluate a CRLM auto-segmentation model on CT scans, to facilitate the clinical adoption of TTV.
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- The study investigates how metabolic tumor volume (MTV) of liver metastases from F-FDG PET/CT can predict long-term survival outcomes (disease-free survival, overall survival, and survival after relapse) in colorectal cancer patients after liver transplantation.
- It finds that patients with low MTV and a low number of metastases have significantly longer overall survival (151 months) compared to those with high MTV (26 months).
- Additionally, even patients with a high number of metastases can experience favorable survival outcomes if they maintain a low MTV, suggesting that MTV could be a critical factor in prognosis after liver transplantation.
Background: Guidelines are inconclusive on whether contrast-enhanced MRI using gadoxetic acid and diffusion-weighted imaging should be added routinely to CT in the investigation of patients with colorectal liver metastases who are scheduled for curative liver resection or thermal ablation, or both. Although contrast-enhanced MRI is reportedly superior than contrast-enhanced CT in the detection and characterisation of colorectal liver metastases, its effect on clinical patient management is unknown. We aimed to assess the clinical effect of an additional liver contrast-enhanced MRI on local treatment plan in patients with colorectal liver metastases amenable to local treatment, based on contrast-enhanced CT.
View Article and Find Full Text PDFImportance: Liver transplant for colorectal cancer with liver metastases was abandoned in the 1990s due to poor overall survival. From 2006, liver transplant for in nonresectable colorectal liver metastases has been reexamined through different prospective trials.
Objective: To determine predictive factors for transplant long-term survival and cure after liver transplant.