Publications by authors named "T Susini"

Background: Pregnancy-associated breast cancer (PABC), with an incidence rate from 1:3,000 to 1:10,000 deliveries, is the most frequent cancer during pregnancy. PABC appropriate management must take into consideration both the maternal oncological safety and the fetal health, thus posing a challenge for the mother, the baby, and the clinicians. The treatment should adhere as closely as possible to the breast cancer (BC) guidelines.

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Breast cancer (BC) is a leading topic in medical research as it is the most common cancer occurring in women worldwide; its incidence is progressively increasing in all age groups [...

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Breast lesions of uncertain malignant potential (B3) are frequently diagnosed in the era of breast cancer (BC) screening and their management is controversial. They are generally removed surgically, but some international organizations and guidelines for breast research suggest follow-up care alone or, more recently, propose vacuum-assisted excision (VAE). The risk of upgrade to BC is known, but very little data exist on its role as risk factor for future BC development.

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Article Synopsis
  • Sentinel lymph node biopsy (SLNB) has shifted from using intraoperative frozen section (FS) to delayed permanent section (PS) analysis for breast cancer staging, with FS used selectively for high-risk cases.
  • A study analyzed data from 2004 to 2020, revealing that switching to PS dramatically reduced the need for subsequent axillary dissection and decreased operative time without affecting re-operation rates or survival outcomes.
  • The findings suggest that PS-SLNB is a safer and more efficient approach, offering both patient and healthcare system benefits while maintaining the same survivorship and recurrence rates.
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Breast cancer (BC) has overtaken lung cancer as the most common cancer in the world and the projected incidence rates show a further increase. Early detection through population screening remains the cornerstone of BC control, but a progressive change from early diagnosis only-based to a personalized preventive and risk-reducing approach is widely debated. Risk-stratification models, which also include personal lifestyle risk factors, are under evaluation, although the documentation burden to gather population-based data is relevant and traditional data collection methods show some limitations.

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