Publications by authors named "T Sumiya"
Article Synopsis
- Researchers focused on developing new inhibitors for lysine methyltransferase G9a, which plays a significant role in epigenetics.
- They improved an existing compound (7a) to create a much more effective inhibitor (7i), which has a low IC value of 0.024 μM, indicating strong potency.
- Studies using X-ray crystallography and SPR showed that 7i binds to G9a differently than other compounds, and it effectively reduced certain histone modifications and increased γ-globin mRNA levels in specific human cells.
Article Synopsis
- Massive hemoptysis is a serious complication of lung cancer, often leading to fatal outcomes with no standard treatment available.
- A 63-year-old man with lung cancer developed massive hemoptysis and was successfully treated using Veno-Venous Extra Corporeal Membrane Oxygenation (V-V ECMO) and radiation therapy, despite being deemed inoperable.
- The patient was discharged two months after treatment, living without recurrence of hemoptysis until he passed away a year later due to other cancer-related complications.
A female patient in her 50 s was found to have a 10-cm tumor resulting from locally advanced cervical cancer (LACC). Three-year relapse-free survival was achieved following a multimodal treatment strategy integrating chemoradiotherapy (CRT), regional hyperthermia (RHT), and interstitial brachytherapy (ISBT). Given the large size of the tumor, enhancement of the geometrical dose distribution was anticipated using ISBT.
View Article and Find Full Text PDF[Proposal] Here, we retrospectively evaluate risk factors for radiation necrosis and local recurrence after PBT for skull base chordoma or chondrosarcoma. [Patients and Methods] We analyzed 101 patients who received PBT for skull base chordomas and chondrosarcomas from January 1989 to February 2021. Multivariable logistic regression models were applied for local recurrence, temporal lobe radiation necrosis rates, and temporal lobe radiation necrosis.
View Article and Find Full Text PDFBackground Abnormal sensations were frequently experienced by patients who received irradiation of the brain or head and neck region. We have previously suggested correlations with irradiation of the nasal cavity and retina. Purpose We performed a retrospective dose-volume histogram analysis focused on the brain and head and neck tumor to examine the relationship between these abnormal sensations and the details of irradiation.
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