Folate receptor-targeted and pH-tunable dextran modified geraniol-protein nano-scaffolds stir up oxidative assault and apoptotic killing of HCT-116 colorectal cancer cells.

Colorectal cancer, the second prime catastrophic cause of cancer-related mortality worldwide, manifests resistance to standard chemotherapy leading to poor patient outcomes. Mono-terpenoid alcohol geraniol, a cardinal ingredient of many essential oils, is active against various cancers and can induce apoptotic events and trigger oxidative assault in striving against cancer. However, its clinical application is restricted due to its indigent bioavailability and non-specific biodistribution.

Dopamine Toxicity Induces ROS-Dependent Death of Murine Neuroblastoma Cells: Impact on the Interactions of Cofilin With UCHL1 and MMP9.

The death of dopaminergic neurons, a hallmark event during Parkinson's disease (PD), leads to increased dopamine concentration in the neuronal micro-environment. Keeping this in mind, we intend to understand the impact of elevated dopamine concentration on molecular interactions among proteins and the stability of the neuronal cytoskeleton. We used differentiated N2A cells and exposed them to 100 µM DA for 24 h.

Evaluation of treatment outcomes and associated risk factors in children with TB in Bangladesh.

Background: Children aged 0-14 years old make up 4% of the total number of people diagnosed with TB in Bangladesh. Local pediatric treatment outcomes and associated factors are poorly understood; further understanding can inform tailored interventions to close delivery gaps.

Methods: To assess the risk factors for unsuccessful treatment outcomes among children receiving TB treatment in 119 health facilities in Mymensingh Division, we conducted systematic verbal screening from 2018 to 2021.

Racial Variability in Platelet Response Among Patients With Peripheral Artery Disease.

Introduction: Peripheral artery disease (PAD) is prevalent among the elderly population, with Black Americans facing a higher incidence and complications than White Americans. Antiplatelet therapy is crucial for PAD. This observational study aims to discern racial variability in platelet function using viscoelastic assays in patients' postrevascularization for PAD.

Centimeter-Scale Ultrathin Platinum Monosulfide Films with Large Negative Temperature Coefficient of Resistance for Deformable Visible-to-Mid-Infrared Photodetectors.

Broadband photodetectors covering a spectrum range of visible-to-mid-infrared (Mid-IR) are widely utilized for a range of applications, such as chemical sensing and medical devices. As their physical form factors evolve, a variety of photoresponsive electronic materials have been explored to adapt their demanded mechanical deformability. Herein, we report on a chemical vapor deposition (CVD) growth of centimeter-sized ultrathin (i.