Publications by authors named "T Suhara"
Background: There is no consensus regarding the choice of anesthetic method for patients with pulmonary hypertension (PH). We report two cases in which neuraxial anesthesia was safely performed without general anesthesia during open abdominal surgery in patients with severe PH.
Case Presentation: Case 1: A 59-year-old woman had an atrial septal defect and a huge abdominal tumor with a mean pulmonary arterial pressure (PAP) of 39 mmHg and pulmonary vascular resistance (PVR) of 3.
Article Synopsis
- Duplication of chromosome 15q11-13 is linked to autism spectrum disorder (ASD) and was studied in a mouse model known as 15q dup mice.
- The study involved behavioral tests for anxiety and social interactions, alongside MRI scans, to explore the connection between brain structure and behavior in these mice.
- Findings showed that 15q dup mice exhibited higher anxiety levels and varied social behaviors, with a correlation found between lower sociability and reduced gray matter in a specific brain region, highlighting the complexities of ASD's behavioral diversity.
Article Synopsis
- Visual object memory is crucial for various cognitive skills, and while the anterior temporal cortex's role has been studied in primates, the full picture including large-scale networks and neuronal dynamics is still unclear.
- Researchers found that the orbitofrontal node works closely with the anterior temporal node for object memory by using functional imaging and a short-term memory task in male macaques.
- Silencing the orbitofrontal node disrupted performance on memory tasks by affecting the anterior temporal cortex's function, demonstrating its significant role in enhancing memory signals while not altering perceptual processing.
Article Synopsis
- A new small-molecule ligand called C05-05 has been developed to visualize α-synuclein deposits in the brains of living subjects, which is important for understanding Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
- In studies involving mouse and marmoset models, C05-05 enabled detection of dynamic changes in α-synuclein fibril formation and structural disruptions within neural pathways.
- PET imaging revealed that C05-05 signals were significantly stronger in the midbrains of PD and DLB patients compared to healthy individuals, suggesting its potential for diagnostic and therapeutic advancements in these conditions.
Acute glycemic control significantly affects the clinical outcomes of critically ill patients. This updated network meta-analysis examines the benefits and harms of four target blood glucose levels (< 110, 110-144, 144-180, and > 180 mg/dL). Analyzing data of 27,541 patients from 37 trials, the surface under the cumulative ranking curve for mortality and hypoglycemia was highest at a target blood glucose level of 144-180 mg/dL, while for infection and acute kidney injury at 110-144 mg/dL.
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