Publications by authors named "T Sugisaki"
Nerve conduction studies (NCS) are the standard method for diagnosing diabetic polyneuropathy. Because a clear association between handgrip strength and diabetic neuropathy can serve as a screening tool, the present study evaluated the association between handgrip strength and NCS and diabetes-related complications. A total of 436 patients with type 2 diabetes (T2D) who were admitted to our hospital between April 1, 2018 and March 31, 2023, and evaluated using Baba's diabetic neuropathy classification (BDC) were included.
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- Perioperative FEC therapy is a common treatment for breast cancer, but over 20% of patients experience febrile neutropenia (FN), which pegfilgrastim is often used to prevent.
- A study on pegfilgrastim's long-term safety found no significant differences in blood cell counts or long-term effects after one year of use.
- Pegfilgrastim administration significantly reduced the incidence of FN (6.5% with pegfilgrastim vs. 22.8% without), indicating it can be safely used for one year in breast cancer patients undergoing chemotherapy.
Cost of Pegfilgrastim for the Prophylaxis of Chemotherapy-induced Febrile Neutropenia in Patients with Breast Cancer Receiving Perioperative Chemotherapy in Daily Practice in Japan: A Posthoc Analysis in a Single-center Retrospective Study.
Yakugaku Zasshi
September 2024
Article Synopsis
- A study investigated the costs and survival outcomes associated with pegfilgrastim prophylaxis for febrile neutropenia (FN) in breast cancer patients undergoing chemotherapy in Japan.
- The pegfilgrastim group had higher median total medical costs compared to the non-pegfilgrastim group but did not show a significant difference in FN hospitalization costs.
- Despite increased costs, there was no significant difference in 3-year overall survival rates between the two groups, suggesting pegfilgrastim should be used selectively based on individual FN risk factors rather than routinely.
Article Synopsis
- * Conducted at the Cancer Institute Hospital in Japan, the study analyzed 45 ovarian cancer patients, revealing that over half experienced ≥Grade 3 hematologic toxicity, primarily neutropenia, anemia, and thrombocytopenia.
- * A significant finding was that patients with Grade 4 toxicity had higher serum creatinine ratios, suggesting that monitoring these ratios could help predict severe side effects from niraparib treatment.
Most primary hypothyroidism in adults is caused by chronic thyroiditis. Autoantibodies such as anti-thyroglobulin antibody (TgAb) and anti-thyroid peroxidase antibody (TPOAb) are involved in the pathogenesis of chronic thyroiditis. On the other hand, the clinical features of antibody-negative hypothyroidism are not clear.
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