The impact of neoadjuvant therapy in patients with left-sided resectable pancreatic cancer: an international multicenter study.

Purpose: To assess the association between neoadjuvant therapy and overall survival (OS) in patients with left-sided resectable pancreatic cancer (RPC) compared to upfront surgery.

Background: Left-sided pancreatic cancer is associated with worse OS compared to right-sided pancreatic cancer. Although neoadjuvant therapy is currently seen as not effective in patients with RPC, current randomized trials included mostly patients with right-sided RPC.

Effectiveness of the Facility for Elderly Surveillance System (FESSy) in Two Public Health Center Jurisdictions in Japan: Prospective Observational Study.

Background: Residents of facilities for older people are vulnerable to COVID-19 outbreaks. Nevertheless, timely recognition of outbreaks at facilities for older people at public health centers has been impossible in Japan since May 8, 2023, when the Japanese government discontinued aggressive countermeasures against COVID-19 because of the waning severity of the dominant Omicron strain. The Facility for Elderly Surveillance System (FESSy) has been developed to improve information collection.

Hepatocellular Carcinoma Presenting with Pseudoprogression in a Patient Receiving Atezolizumab Plus Bevacizumab Combination Therapy.

A 65-year-old man with hepatocellular carcinoma and lung metastasis was treated with a combination of atezolizumab and bevacizumab. Subsequently, the patient developed fever and new liver lesions, which were considered to indicate a pseudoprogression. Despite this, the treatment was continued.

Oral administration of astaxanthin mitigates chronological skin aging in mice.

Intrinsic skin aging is a chronological decline in skin texture and function influenced largely by genetic factors. Aged skin exhibits morphological alterations, including wrinkling, dryness, and roughness, along with dysfunctional changes in the skin barrier. In this study, the in vivo anti-intrinsic aging efficacy of dietary astaxanthin extracted from Haematococcus pluvialis on the skin was evaluated using aged C57BL/6 J mice.

Evaluating air leakage from staple line reinforcements in anatomical pulmonary resection (AIRSTOP): a prospective randomized controlled trial protocol.

Background: Air leakage during pulmonary resection is a major complication in thoracic surgery. It frequently occurs at sites of adhesion dissection, due to lung manipulation, and along the staple lines of automatic suturing devices, particularly in cases of pulmonary fragility such as those of emphysema and interstitial pneumonia. Persistent postoperative air leakage prolongs chest tube indwelling and extends hospitalization time.