Publications by authors named "T Sugasawa"
Background: Persistent physical fatigue (PPhF) accompanying daily intensive training often results in underperformance. While salivary secretory immunoglobulin A (SIgA) has been traditionally used as an immunological marker, salivary human herpesvirus 6 and/or 7 (HHV-6/7) have recently been presented as "microbiological" markers of PPhF. This study aimed to examine the monthly variabilities of salivary HHV-6/7 levels and the difference with SIgA along the training periodization.
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- Autonomously replicating sequences (ARSs) are crucial for the replication and stability of episomal vectors in organisms, but no ARS information has previously been reported for diatoms.
- In this study, researchers used chromatin immunoprecipitation sequencing to identify ARS candidates in the model diatom Phaeodactylum tricornutum, focusing on subunits ORC2 and ORC4, which bound to 355 genomic sites.
- Of those, 69 sites showed consistent screening results, revealing that these ARS candidates have an AT-richness of about 50% and unique characteristics compared to ARSs in other eukaryotes, indicating a distinct nature in diatom ARSs.
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- Medical care for domestic dogs is now viewed as comparable to human medical care, emphasizing the importance of advanced testing methods for their health.* -
- This study aimed to develop a non-invasive technique for determining whole mitochondrial DNA (mtDNA) sequences using fecal samples from two Japanese domestic dogs.* -
- Results showed that fecal samples could accurately provide mtDNA sequences, indicating potential applications for diagnosing mitochondrial diseases and identifying individual dogs in future veterinary care.*
Muscle regeneration depends on muscle stem cell (MuSC) activity. Myogenic regulatory factors, including myoblast determination protein 1 (MyoD), regulate the fate transition of MuSCs. However, the direct target of MYOD in the process is not completely clear.
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- Recent advancements in gene therapy pose a risk for misuse in sports doping, highlighting the need for improved testing methods.
- Researchers aimed to create a gene doping model using a specific viral vector (rAAV9-h) in mice, which resulted in noticeable changes indicating successful genetic manipulation.
- The study established direct and indirect detection methods for gene doping through advanced qPCR assays, laying groundwork for future testing in athletes.